WASHINGTON — (CNN) Democrats made Hillary Clinton the first female presidential nominee of a major party in the nation’s history on Tuesday, shattering one of the last remaining glass ceilings in American politics.

The former first lady, New York senator and secretary of state was formally installed as the party nominee to take on Donald Trump on an emotional night at the Democratic convention in Philadelphia.

Clinton will formally accept the nomination on Thursday night, before embarking on an intense fall campaign with polls showing her clash with Republican nominee Trump is, for now, too close to call.

South Dakota put Clinton over the top of the 2,382 delegates needed to win the nomination.

The roll call will continue through the full roster of states and territories.

Sen. Barbara Mikulski of Maryland emphasized the historic nature of the moment in nominating Clinton Tuesday afternoon.

“On behalf of all the women who’ve broken down barriers for others, and with an eye toward the barriers still ahead, I proudly place Hillary Clinton’s name in nomination to be the next President of the United States of America,” Mikulski said.

Nancy Pelosi, a history maker in her own right after becoming the highest ranking woman in the history of the US government when she was elected House speaker in 2007, was overcome with emotion as she contemplated Clinton’s achievement.

“It’s beyond thrilling. It’s very exciting and to see at the end she’s the nominee. It’s going to be spectacular,” Pelosi told CNN’s Dana Bash.

“It’s pretty exciting … she’s the best.”

As part of the push to bring Democrats together, following repeated shows of dissent from disenchanted Sanders supporters from the floor on Monday, the Vermont senator’s campaign is asking for his home state to go last in the roll call.

He would move for Clinton to be acclaimed the party nominee unanimously, his spokesman Michael Briggs said Tuesday.

Such a move would reprise Clinton’s similar gesture at the 2008 Democratic National Convention in Denver, after her own divisive primary duel against then-Sen. Barack Obama.

Each state in the roll call will be called in alphabetical order to announce their vote tally for Clinton and Sanders — a process that will eventually bring the former secretary of state over the delegate threshold to clinch the nomination over Sanders.

The self-proclaimed democratic socialist won nearly 2,000 delegates during his insurgent campaign, but told his supporters on Monday night in that they had no choice but to unite around Clinton to ensure the defeat of GOP nominee Donald Trump.

The nominating formalities on Tuesday night will mark a moment of vindication for Clinton who emerged from the wreckage of her unsuccessful 2008 bid — in which she started out as highly favored — to serve as secretary of state in Obama’s “Team of Rivals” cabinet.

But she faces a grueling campaign against Trump, who has engineered a polling bounce after his own convention in Cleveland last week and is now locked in a close race with the soon to be Democratic nominee.

Clinton can however draw on political lesson learned after her long career in the glare of the public spotlight.

This year, the Clinton campaign and the candidate herself appeared determined to apply the lessons from her defeat eight years ago to her second White House bid, running a notably different campaign.

Hillary Clinton has one big advantage over Donald Trump heading into November: hindsight.

Clinton has also undertaken a personal journey since her losing effort eight years ago.

Clinton’s daughter, Chelsea, got married and gave birth to two children.

The experience of becoming a grandmother, in particular, seems to have softened Clinton as a candidate, helping her become more comfortable grounding her candidacy on her personal background and family story.

After she crossed the threshold to clinch her party’s nomination in June, Clinton’s victory speech drew inspiration from her late mother.

“I wish she could see her daughter become the Democratic nominee,” Clinton said of Dorothy Rodham, in a striking departure from 2008 when she was reticent to discuss her mother.

The political drama with Sanders and controversy over Democratic National Committee emails that show staffers has done little to dampen the excitement among Clinton allies.

Michigan Democratic Rep. Dan Kildee told CNN on the floor of the convention that this is a moment in American history that “we should not take lightly or take for granted.”

New Hampshire state Sen. Donna Soucy, a Clinton delegate, is holding a handmade sign tonight that refers to Clinton as first lady, senator, secretary of state and president.

“It means a lot for me personally,” Soucy told CNN. “Tonight is the night when Hillary Clinton will break the glass ceiling for every woman and girl in this country.”

Louisiana Clinton delegate Sheryl Abschire, 65, said she was a Clinton delegate in 2008 and was not sure she would live to see a woman nominated or elected president.

Abschire was crying after she and other Louisiana delegates cast their votes Tuesday.

“This is a very emotional day for me,” she said. “It’s a generational thing for me. My grandmother told me about how her grandmother could not vote. So for me to be here to support the first woman nominee and what I believe will be the first woman president means everything to me.”