WATCH: British PM David Cameron Resigns As Britons Vote To Leave E.U.

LONDON — (CNN) David Cameron has announced his resignation as Prime Minister following the UK’s historic vote to leave the EU.

He refused to give an exact time table for his departure, but said that he wanted a new leader to be in place by the start of the Tory Party conference in October.

In his statement, delivered outside the front door of 10 Downing Street, he said that “the British people have voted to leave the EU and their will must be respected… the will of the British people is an instruction which must be delivered.”

“There can be no doubt about the result.”

He reassured markets and investors, saying that Britain’s economy was strong and also pledged that there would be no sudden change in circumstance either for Britons who live abroad or Europeans who live in the UK.

Historic vote

51.89% of the population voted to leave the European Union, while 48.11% voted to remain. Almost 46.5 million people were registered to vote in Thursday’s referendum.

Pro-“Brexit” campaigners cheered, but the largely unexpected decision played havoc on world markets. London’s FTSE 100 index plunged by more than 8% at the open, with bank stocks getting hit particularly hard.

Pro-independence party UKIP leader and Leave campaigner Nigel Farage told a group of journalists at Westminster following the Leave side’s victory that the EU is “dying.”

Calling for a ‘Brexit government,’ he added that “we’ve given ourselves the chance to rejoin the world … June 23rd needs to become a national bank holiday and we will call it Independence Day.”

The result reflects a deeply divided union.

In one of the most divisive campaigns in recent memory, polls had consistently shown voters split down the middle, with the outcome too close to call, and wavering voters likely to determine the result.

The UK has been a member of the European Union — and its precursors — since 1973.

Mixed reaction

The results have prompted mixed reaction from politicians. London Mayor Sadiq Kahn said that the decision was a “clear message” but urged calm.

European Council President Donald Tusk said the UK’s decision to leave the European Union was “historic, but not a moment for hysterical reactions.

“Today on behalf of the 27 (European) leaders, I can say that we are determined to keep our unity as the 27. For all of us, the union is the framework for our common future.”

The far-right Dutch politician Geert Wilders congratulated the UK on its decision, and called for a Dutch referendum on EU membership.

“We want be in charge of our own country, our own money, our own borders, and our own immigration policy,” he was quoted as saying in a statement on his website.

“If I become prime minister, there will be a referendum in the Netherlands on leaving the European Union as well. Let the Dutch people decide.”

U.S. President Barack Obama “has been briefed” on the results and expects to speak to Cameron later in the day.

Markets start freaking out

The shock development will have profound implications for markets and economies around the world.

Along with the FTSE’s disastrous opening, the pound has plunged more than 12% to below $1.34, its lowest level since 1985. Japan’s Nikkei tanked 6.7%, and Hong Kong’s main index dropped 3.7%. Stock futures indicate that markets in London and New York will also tank when they open for trading. Dow futures are down more than 650 points.

Bank of England Governor Mark Carney said that the body is “well prepared” and “won’t hesitate” to take additional measures as markets adjust.

The “UK financial system is resilient,” he added.

Results have sparked a global markets sell-off. London stock futures are trading 7% lower and stock futures in the U.S. are down 2%, CNNMoney reports.

The pound is dropping sharply against all major currencies, and is currently trading at 1.38 against the dollar. Oil is down 4%.

Gold — one asset investors turn to in the times of uncertainty — is up.

‘Serious consequences’

While Turnout in Scotland is 67% and voted overwhelmingly to stay in Europe. Now that the UK as a whole has determine to leave, many north of the border feel that this would be a catalyst for another Scottish referendum, allowing the country to secede from the UK.

“Scotland has delivered a strong, unequivocal vote to remain in the EU, and I welcome that endorsement of our European status,” Scotland’s First Minister Nicola Sturgeon said in a statement. She will deliver a statement on the Brexit vote’s implications for Scotland later on Friday morning, she said in a statement.

“And while the overall result remains to be declared, the vote here makes clear that the people of Scotland see their future as part of the European Union.”

Her predecessor, Alex Salmond, told British television that Cameron has no choice but to resign after losing the referendum.

“If this result holds, it’s the end of Britain, just simple as that… Scotland is voting overwhelmingly to stay,” historian Simon Schama told CNN before the vote.

“Bye-bye Great Britain, bye-bye United Kingdom. That will absolutely happen.”