WASHINGTON (AP) — President Joe Biden’s pick to head the Office of Management and Budget, Neera Tanden, has withdrawn her nomination after she faced opposition from key Democratic and Republican senators for her controversial tweets.

Her withdrawal marks the first high-profile defeat of one of Biden’s nominees. Eleven of the 23 Cabinet nominees requiring Senate approval have been confirmed, most with strong bipartisan support.

“Unfortunately, it now seems clear that there is no path forward to gain confirmation, and I do not want continued consideration of my nomination to be a distraction from your other priorities,” Tanden wrote in a letter to Biden. The president, in a statement, said he has “utmost respect for her record of accomplishment, her experience and her counsel” and pledged to find her another role in his administration.

Tanden’s viability was in doubt after Democratic West Virginia Sen. Joe Manchin and a number of moderate Republicans came out against her last month, all citing her tweets attacking members of both parties prior to her nomination.

Manchin, a key moderate swing vote in the Senate, said last month in a statement announcing his opposition that “her overtly partisan statements will have a toxic and detrimental impact on the important working relationship between members of Congress and the next director of the Office of Management and Budget.” Maine Republican Sen. Susan Collins, meanwhile, cited Biden’s own standard of conduct in opposing Tanden, declaring in a statement that “her past actions have demonstrated exactly the kind of animosity that President Biden has pledged to transcend.”

Tanden needed just 51 votes in an evenly-divided Senate, with Vice President Kamala Harris acting as a tiebreaker. But without Manchin’s support, the White House was left scrambling to find a Republican to support her.

One potential Republican vote, Sen. Lisa Murkowski of Alaska, told reporters earlier Tuesday on Capitol Hill she still had not yet made up her mind on Tanden’s nomination.

The White House stuck with her even after a number of centrist Republicans made their opposition known, insisting her experience growing up on welfare and background working on progressive policies as the president and CEO of the liberal-leaning Center for American Progress made her the right candidate for the moment. White House chief of staff Ron Klain initially insisted the administration was “fighting our guts out” for her.

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